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Foto på Victor Olariu

Victor Olariu

Universitetslektor

Foto på Victor Olariu

Neural tube patterning : from a minimal model for rostrocaudal patterning toward an integrated 3D model

Författare

  • Max Brambach
  • Ariane Ernst
  • Sara Nolbrant
  • Janelle Drouin-Ouellet
  • Agnete Kirkeby
  • Malin Parmar
  • Victor Olariu

Summary, in English

Rostrocaudal patterning of the neural tube is a defining event in vertebrate brain development. This process is driven by morphogen gradients which specify the fate of neural progenitor cells, leading to the partitioning of the tube. Although this is extensively studied experimentally, an integrated view of the genetic circuitry is lacking. Here, we present a minimal gene regulatory model for rostrocaudal patterning, whose tristable topology was determined in a data-driven way. Using this model, we identified the repression of hindbrain fate as promising strategy for the improvement of current protocols for the generation of dopaminergic neurons. Furthermore, we combined our model with an established minimal model for dorsoventral patterning on a realistic 3D neural tube and found that key features of neural tube patterning could be recapitulated. Doing so, we demonstrate how data and models from different sources can be combined to simulate complex in vivo processes.

Avdelning/ar

  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • Utvecklings- och regenerativ neurobiologi
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Human neural utvecklingsbiologi
  • Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

Publiceringsår

2021-06-25

Språk

Engelska

Publikation/Tidskrift/Serie

iScience

Volym

24

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Developmental Biology
  • Cell and Molecular Biology
  • Other Physics Topics

Nyckelord

  • biophysics
  • neurogenetics
  • systems neuroscience

Status

Published

Forskningsgrupp

  • Developmental and Regenerative Neurobiology
  • Human Neural Developmental Biology

ISBN/ISSN/Övrigt

  • ISSN: 2589-0042