Patrik Edén
Universitetslektor
Gene expression profiling indicates that immunohistochemical expression of CD40 is a marker of an inflammatory reaction in the tumor stroma of diffuse large B-cell lymphoma
Författare
Summary, in English
Immunohistochemical expression of CD40 is seen in 60-70% of diffuse large B-cell lymphoma (DLBCL) and is associated with a superior prognosis. By using gene expression profiling we aimed to further explore the underlying mechanisms for this effect. Ninety-eight immunohistochemically defined CD40 positive or negative DLBCL tumors, 63 and 35 respectively, were examined using spotted 55K oligonucleotide arrays. CD40 expressing tumors were characterized by up-regulated expression of genes encoding proteins involved in cell-matrix interactions: collagens, integrin a V, proteoglycans and proteolytic enzymes, and antigen presentation. Immunohistochemistry confirmed that CD40 positive tumors co-express the proinflammatory proteoglycan biglycan (p = 0.005), which in turn correlates with the amount of infiltrating macrophages and CD4 and CD8 positive T-cells. We postulate that immunohistochemical expression of CD40 mainly reflects the inflammatory status in tumors. A high intratumoral inflammatory reaction may correlate with an increased autologous tumor response, and thereby a better prognosis.
Avdelning/ar
- Lymfom - Klinisk forskning
- Bröstcancer-genetik
- Tumörmikromiljö
- Computational Biology and Biological Physics - Has been reorganised
Publiceringsår
2012
Språk
Engelska
Sidor
1764-1768
Publikation/Tidskrift/Serie
Leukemia & Lymphoma
Volym
53
Avvikelse
9
Dokumenttyp
Artikel i tidskrift
Förlag
Taylor & Francis
Ämne
- Cancer and Oncology
Nyckelord
- Diffuse large B-cell lymphoma
- CD40
- gene expression profiling
- tumor
- stroma
Aktiv
Published
Forskningsgrupp
- Lymphoma - Clinical Research
ISBN/ISSN/Övrigt
- ISSN: 1042-8194