Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans

Summary, in English

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO₂) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO₂ in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO₂ during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.

• Författare: Aboma Merdasa; Josefine Bunke; Magdalena Naumovska; John Albinsson; Tobias Erlöv; Magnus Cinthio; Nina Reistad; Rafi Sheikh; Malin Malmsjö
• Avdelning/ar: Oftalmologi, Lund; Forskargruppen för oftalmologisk avbildning; Förbränningsfysik; Kemisk fysik; Avdelningen för Biomedicinsk teknik; Centrum för miljö- och klimatvetenskap (CEC); Atomfysik; Fysiska institutionen; Klinisk och experimentell lungtransplantation; NPWT teknologin
• Publiceringsår: 2021
• Språk: Engelska
• Sidor: 2484-2495
• Publikation/Tidskrift/Serie: Biomedical Optics Express
• Volym: 12
• Issue: 4
• Länkar: http://dx.doi.org/10.1364/BOE.418397
• Dokumenttyp: Artikel i tidskrift
• Förlag: Optical Society of America
• Ämne: Medical Biotechnology
• Aktiv: Published
• Forskningsgrupp: Ophthalmology Imaging Research Group; Clinical and experimental lung transplantation; NPWT technology
• ISBN/ISSN/Övrigt: ISSN: 2156-7085