Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Foto av Nina Reistad

Nina Reistad

Universitetslektor

Foto av Nina Reistad

Photoacoustic imaging for the monitoring of local changes in oxygen saturation following an adrenaline injection in human forearm skin

Författare

  • Josefine Bunke
  • Aboma Merdasa
  • Rafi Sheikh
  • John Albinsson
  • Tobias Erlöv
  • Bodil Gesslein
  • Magnus Cinthio
  • Nina Reistad
  • Malin Malmsjö

Summary, in English

Clinical monitoring of blood oxygen saturation (sO2) is traditionally performed using optical techniques, such as pulse oximetry and diffuse reflectance spectroscopy (DRS), which lack spatial resolution. Photoacoustic imaging (PAI) is a rapidly developing biomedical imaging technique that is superior to previous techniques in that it combines optical excitation and acoustic detection, providing a map of chromophore distribution in the tissue. Hitherto, PAI has primarily been used in preclinical studies, and only a few studies have been performed in patients. Its ability to measure sO2 with spatial resolution during local vasoconstriction after adrenaline injection has not yet been investigated. Using PAI and spectral unmixing we characterize the heterogeneous change in sO2 after injecting a local anesthetic containing adrenaline into the dermis on the forearm of seven healthy subjects. In comparison to results obtained using DRS, we highlight contrasting results obtained between the two methods arising due to the so-called ‘window effect’ caused by a reduced blood flow in the superficial vascular plexus. The results demonstrate the importance of spatially resolving sO2 and the ability of PAI to assess the tissue composition in different layers of the skin.

Avdelning/ar

  • Forskargruppen för oftalmologisk avbildning
  • Oftalmologi, Lund
  • Förbränningsfysik
  • Avdelningen för Biomedicinsk teknik
  • Centrum för miljö- och klimatvetenskap (CEC)
  • Atomfysik
  • Fysiska institutionen

Publiceringsår

2021-07-01

Språk

Engelska

Sidor

4084-4096

Publikation/Tidskrift/Serie

Biomedical Optics Express

Volym

12

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Optical Society of America

Ämne

  • Medical Biotechnology

Nyckelord

  • Diffuse optical tomography
  • Diffuse reflectance spectroscopy
  • Imaging techniques
  • Magnetic resonance imaging
  • Medical imaging
  • Speckle imaging

Aktiv

Published

Forskningsgrupp

  • Ophthalmology Imaging Research Group

ISBN/ISSN/Övrigt

  • ISSN: 2156-7085