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Foto av Nina Reistad

Nina Reistad

Universitetslektor

Foto av Nina Reistad

Identification of tumor margins using diffuse reflectance spectroscopy with an extended-wavelength spectrum in a porcine model

Författare

  • U Dahlstrand
  • R Sheikh
  • C D Nguyen
  • J Hult
  • N Reistad
  • M Malmsjö

Summary, in English

OBJECTIVE: A novel extended-wavelength diffuse reflectance spectroscopy (EWDRS) technique is being developed for future clinical non-invasive tumor margin delineation. In this study, the ability of EWDRS to identify the margins of pigmented skin lesions in an in vivo pig model was evaluated.

MATERIALS AND METHODS: Extended-wavelength diffuse reflectance spectroscopy recordings (350-1550 nm) were made on 13 pigmented skin lesions and non-pigmented skin, as a reference. The hand-held probe was swept toward the pigmented area until the signal changed, thus indicating that the margin had been identified. A needle was inserted as a marker, and tissue samples were sent for histological analysis. The distance between the EWDRS-defined border and the histological border was measured by 3 independent examiners.

RESULTS: The median difference between the EWDRS-defined border and the histological border was 70 μm toward the pigmented tissue (range: -579 to 538 μm). A Pearson correlation coefficient of .95 was obtained for the examiners.

CONCLUSIONS: Extended-wavelength diffuse reflectance spectroscopy can be used in vivo to delineate the border of pigmented skin lesions in a porcine model with high accuracy, indicating that it may be a useful tool for non-invasive tumor margin delineation in the future.

Avdelning/ar

  • Forskargruppen för oftalmologisk avbildning
  • Oftalmologi, Lund
  • Atomfysik
  • Nationellt Resurscentrum för Fysik
  • Klinisk och experimentell lungtransplantation
  • NPWT teknologin

Publiceringsår

2018

Språk

Engelska

Sidor

667-671

Publikation/Tidskrift/Serie

Skin Research and Technology

Volym

24

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Ophthalmology
  • Biomedical Laboratory Science/Technology

Nyckelord

  • Journal Article

Aktiv

Published

Forskningsgrupp

  • Ophthalmology Imaging Research Group
  • Clinical and experimental lung transplantation
  • NPWT technology

ISBN/ISSN/Övrigt

  • ISSN: 0909-752X