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Foto på Mattias Ohlsson

Mattias Ohlsson

Professor

Foto på Mattias Ohlsson

Statistical power considerations in genotype-based recall randomized controlled trials

Författare

  • Naeimeh Atabaki-Pasdar
  • Mattias Ohlsson
  • Dmitry Shungin
  • Azra Kurbasic
  • Erik Ingelsson
  • Ewan R. Pearson
  • Ashfaq Ali
  • Paul W. Franks

Summary, in English

Randomized controlled trials (RCT) are often underpowered for validating gene-treatment interactions. Using published data from the Diabetes Prevention Program (DPP), we examined power in conventional and genotype-based recall (GBR) trials. We calculated sample size and statistical power for gene-metformin interactions (vs. placebo) using incidence rates, gene-drug interaction effect estimates and allele frequencies reported in the DPP for the rs8065082 SLC47A1 variant, a metformin transported encoding locus. We then calculated statistical power for interactions between genetic risk scores (GRS), metformin treatment and intensive lifestyle intervention (ILI) given a range of sampling frames, clinical trial sample sizes, interaction effect estimates, and allele frequencies; outcomes were type 2 diabetes incidence (time-to-event) and change in small LDL particles (continuous outcome). Thereafter, we compared two recruitment frameworks: GBR (participants recruited from the extremes of a GRS distribution) and conventional sampling (participants recruited without explicit emphasis on genetic characteristics). We further examined the influence of outcome measurement error on statistical power. Under most simulated scenarios, GBR trials have substantially higher power to observe gene-drug and gene-lifestyle interactions than same-sized conventional RCTs. GBR trials are becoming popular for validation of gene-treatment interactions; our analyses illustrate the strengths and weaknesses of this design.

Avdelning/ar

  • Genetisk och molekylär epidemiologi
  • Beräkningsbiologi och biologisk fysik - Har omorganiserats
  • EXODIAB: Excellence of Diabetes Research in Sweden
  • EpiHealth: Epidemiology for Health

Publiceringsår

2016-11-25

Språk

Engelska

Publikation/Tidskrift/Serie

Scientific Reports

Volym

6

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Medical Genetics
  • Probability Theory and Statistics

Status

Published

Forskningsgrupp

  • Genetic and Molecular Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 2045-2322