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Carsten Peterson

Expert

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Random Boolean network models and the yeast transcriptional network

Författare

  • Stuart Kauffman
  • Carsten Peterson
  • Björn Samuelsson
  • Carl Troein

Summary, in English

The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that, for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state, regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.

Avdelning/ar

  • Computational Biology and Biological Physics - Has been reorganised
  • Functional zoology

Publiceringsår

2003

Språk

Engelska

Sidor

14796-14799

Publikation/Tidskrift/Serie

Proceedings of the National Academy of Sciences

Volym

100

Issue

25

Dokumenttyp

Artikel i tidskrift

Förlag

National Academy of Sciences

Ämne

  • Zoology
  • Biophysics

Nyckelord

  • genetic networks
  • dynamical systems

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 1091-6490