Carsten Peterson
Expert
Folding and design in coarse-grained protein models
Författare
Summary, in English
Recent advances in coarse-grained lattice and off-lattice protein models are reviewed. The sequence dependence of thermodynamical folding properties are investigated and evidence for non-randomness of the binary sequences of good folders are discussed. Similar patterns for non-randomness are found for real proteins. Dynamical parameter MC methods, such as the tempering and multisequence algorithms, are essential in order to obtain these results. Also, a new MC method for design, the inverse of folding, is presented. Here, one maximizes conditional probabilities rather than minimizing energies. By construction, this method ensures that the designed sequences represent good folders thermodynamically.
Avdelning/ar
- Institutionen för astronomi och teoretisk fysik - Har omorganiserats
Publiceringsår
2000-01-01
Språk
Engelska
Sidor
712-714
Publikation/Tidskrift/Serie
Nuclear Physics B - Proceedings Supplements
Volym
83-84
Issue
1-3
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biophysics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0920-5632