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Carsten Peterson

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Folding and design in coarse-grained protein models

Författare

  • Carsten Peterson

Summary, in English

Recent advances in coarse-grained lattice and off-lattice protein models are reviewed. The sequence dependence of thermodynamical folding properties are investigated and evidence for non-randomness of the binary sequences of good folders are discussed. Similar patterns for non-randomness are found for real proteins. Dynamical parameter MC methods, such as the tempering and multisequence algorithms, are essential in order to obtain these results. Also, a new MC method for design, the inverse of folding, is presented. Here, one maximizes conditional probabilities rather than minimizing energies. By construction, this method ensures that the designed sequences represent good folders thermodynamically.

Avdelning/ar

  • Department of Astronomy and Theoretical Physics

Publiceringsår

2000-01-01

Språk

Engelska

Sidor

712-714

Publikation/Tidskrift/Serie

Nuclear Physics B - Proceedings Supplements

Volym

83-84

Issue

1-3

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Biophysics

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 0920-5632