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Carsten Peterson

Expert

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Computational multiscale modeling of embryo development.

Författare

  • Pawel Krupinski
  • Vijay Chickarmane
  • Carsten Peterson

Summary, in English

Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.

Avdelning/ar

  • Computational Biology and Biological Physics

Publiceringsår

2012-09-06

Språk

Engelska

Publikation/Tidskrift/Serie

Current Opinion in Genetics & Development

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Medical Genetics

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 1879-0380