My research interests span a wide range of topics around the intersection of biology and computational science. Broadly speaking, my research has been a mixture of coarse-grained and detailed modeling, often involving gene regulatory networks, and development of algorithms and open source software.
Since the beginning of my research career, I have worked with Boolean gene regulatory network models, the HP model of protein folding, stem cell regulation, circadian clocks in plants, plant-pathogen interactions, evolutionary algorithms, degradation of soil organic matter by fungi and methods for processing spectroscopic imaging data. Most of this research has been cross-disciplinary in nature, and I have participated in two interdisciplinary themes: bio-inspired energy conversion and synthetic biology.
The building blocks of my research are things like ODE systems, graph algorithms, parameter optimization and more recently also iterative data processing algorithms and machine learning. My current work is focused on software and algorithms for vibrational spectroscopy imaging in the OCTAVVS project, and as well as biological and medical applications.
As an applications expert at CIPA, the Correlative Image Processing and Analysis software infrastructure at LU, I provide researchers with services within my field of expertise, in particular regarding 2D spectroscopic data processing. Feel free to contact me about developing, combining and visualizing steps such as data loading, pre-processing, dimensionality reduction and AI classification.
For up-to-date information about my supervision and teaching activities, software projects and CV, see my profile in Lund University research portal.
Publications
Displaying of publications. Sorted by year, then title.
Facilitating clinically relevant skin tumor diagnostics with spectroscopy-driven machine learning
Emil Andersson, Jenny Hult, Carl Troein, Magne Stridh, Benjamin Sjögren, et al.
(2024) iScience, 27
Journal articleElucidating fungal decomposition of organic matter at sub-micrometer spatial scales using optical photothermal infrared (O-PTIR) microspectroscopy
Michiel Op De Beeck, Carl Troein, Carsten Peterson, Anders Tunlid, Per Persson
(2024) Applied and Environmental Microbiology, 90
Journal articleSyntetisk biologi - en hållbar lösning på klimatkrisen?
Rajni Hatti-Kaul, Nelida Leiva Eriksson, Ingemar André, Magnus Carlquist, Maria Hedlund, et al.
(2022)
PosterRegulation of fungal decomposition at single-cell level
Michiel Op De Beeck, Carl Troein, Syahril Siregar, Luigi Gentile, Giuseppe Abbondanza, et al.
(2020) ISME Journal, 14 p.896-905
Journal articlePerfect edge-transmitting recombination of permutations
Adriaan Merlevede, Carl Troein
(2020) arXiv
OtherOCTAVVS : A graphical toolbox for high-throughput preprocessing and analysis of vibrational spectroscopy imaging data
Carl Troein, Syahril Siregar, Michiel Op De Beeck, Carsten Peterson, Anders Tunlid, et al.
(2020) Methods and Protocols, 3 p.1-15
Journal articleHomology and linkage in crossover for linear genomes of variable length
Adriaan Merlevede, Henrik Åhl, Carl Troein
(2019) PLoS ONE, 14
Journal articleThe soil organic matter decomposition mechanisms in ectomycorrhizal fungi are tuned for liberating soil organic nitrogen
César Nicolás, Tomas Martin-Bertelsen, Dimitrios Floudas, Johan Bentzer, Mark Smits, et al.
(2018) ISME Journal
Journal articleFenton reaction facilitates organic nitrogen acquisition by an ectomycorrhizal fungus
Michiel Op De Beeck, Carl Troein, Carsten Peterson, Per Persson, Anders Tunlid
(2018) New Phytologist, 218 p.335-343
Journal articleSelection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.
Karl Fogelmark, Carsten Peterson, Carl Troein
(2016) PLoS ONE, 11
Journal articleRethinking transcriptional activation in the Arabidopsis circadian clock.
Karl Fogelmark, Carl Troein
(2014) PLoS Computational Biology, 10
Journal articleLight and circadian regulation of clock components aids flexible responses to environmental signals
Laura E. Dixon, Sarah K. Hodge, Gerben van Ooijen, Carl Troein, Ozgur E. Akman, et al.
(2014) New Phytologist, 203 p.568-577
Journal articleCarbon availability triggers the decomposition of plant litter and assimilation of nitrogen by an ectomycorrhizal fungus
F. Rineau, Firoz Shah, M. M. Smits, Per Persson, Tomas Johansson, et al.
(2013) The Isme Journal, 7 p.2010-2022
Journal articleSBSI: an extensible distributed software infrastructure for parameter estimation in systems biology
Richard Adams, Allan Clark, Azusa Yamaguchi, Neil Hanlon, Nikos Tsorman, et al.
(2013) Bioinformatics, 29 p.664-665
Journal articleOn evaluating models in Computational Morphodynamics.
Henrik Jönsson, Jeremy Gruel, Pawel Krupinski, Carl Troein
(2012) Current Opinion in Plant Biology, 15 p.103-110
Journal articleCircadian rhythms persist without transcription in a eukaryote
John S. O'Neill, Gerben Van Ooijen, Laura E. Dixon, Carl Troein, Florence Corellou, et al.
(2011) Nature, 469 p.554-558
Journal articleMutation-induced fold switching among lattice proteins.
Christian Holzgräfe, Anders Irbäck, Carl Troein
(2011) Journal of Chemical Physics, 135
Journal articleProteasome function is required for biological timing throughout the twenty-four hour cycle
Gerben van Ooijen, Laura E. Dixon, Carl Troein, Andrew J. Millar
(2011) Current Biology, 21 p.869-875
Journal articleMultiple light inputs to a simple clock circuit allow complex biological rhythms
Carl Troein, Florence Corellou, Laura E. Dixon, Gerben van Ooijen, John S. O'Neill, et al.
(2011) Plant Journal, 66 p.375-385
Journal articleWeather and Seasons Together Demand Complex Biological Clocks
Carl Troein, James C.W. Locke, Matthew S. Turner, Andrew J. Millar
(2009) Current Biology, 19 p.1961-1964
Journal articleIs Transcriptional Regulation of Metabolic Pathways and Optimal Strategy for Fitness?
Carl Troein, Dag Ahrén, Morten Krogh, Carsten Peterson
(2007) PLoS ONE, 2
Journal articleTranscriptional dynamics of the embryonic stem cell switch
Vijay Chickarmane, Carl Troein, Ulrike Nuber, Herbert M. Sauro, Carsten Peterson
(2006) PLoS Computational Biology, 2 p.1080-1092
Journal articleAn introduction to BioArray software environment
Carl Troein, Johan Vallon-Christersson, Lao Saal
(2006) Methods in Enzymology, 411 p.99-119
Journal article reviewAn introduction to BASE
Carl Troein, Johan Vallon-Christersson, L. H. Saal
(2006) Methods in Enzymology: DNA Microarrays, Part B: Databases and DNA Microarrays, Part B: Databases and statistics, 411 p.99-119
Book chapterRandom maps and attractors in random Boolean networks
Björn Samuelsson, Carl Troein
(2005) Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), 72
Journal articleSignal transduction pathway profiling of individual tumor samples
Thomas Breslin, Morten Krogh, Carsten Peterson, Carl Troein
(2005) BMC Bioinformatics, 6
Journal articlePHOREST: a web-based tool for comparative analyses of expressed sequence tag data
Dag Ahrén, Carl Troein, Tomas Johansson, Anders Tunlid
(2004) Molecular Ecology Notes, 4 p.311-314
Journal articleGenetic networks with canalyzing Boolean rules are always stable
S Kauffman, Carsten Peterson, Björn Samuelsson, Carl Troein
(2004) Proceedings of the National Academy of Sciences, 101 p.17102-17107
Journal articleRandom Boolean network models and the yeast transcriptional network
Stuart Kauffman, Carsten Peterson, Björn Samuelsson, Carl Troein
(2003) Proceedings of the National Academy of Sciences, 100 p.14796-14799
Journal articleSuperpolynomial growth in the number of attractors in Kauffman networks
Björn Samuelsson, Carl Troein
(2003) Physical Review Letters, 90
Journal articleSuperpolynomial growth in the number of attractors in Kauffman networks (conference report)
Björn Samuelsson, Carl Troein
(2003) Acta Physica Polonica B, 34 p.5051-5061
Journal articleBioarray software environment: a platform for comprehensive management and analysis of microarray data
Lao Saal, Carl Troein, Johan Vallon-Christersson, Sofia Gruvberger, Åke Borg, et al.
(2002) Genome Biology, 3 p.1-2002
Journal articleEnumerating designing sequences in the HP model
Anders Irbäck, Carl Troein
(2002) Journal of Biological Physics, 28 p.1-15
Journal article
Member of COSHE
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CIPA
User support in image processing and image analysis.