Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.
Summary, in English
Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.
- Computational Biology and Biological Physics - Undergoing reorganization
Public Library of Science (PLoS)
- Bioinformatics and Systems Biology
- Other Physics Topics
- ISSN: 1932-6203