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Carl Troein

Researcher

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Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.

Author

  • Karl Fogelmark
  • Carsten Peterson
  • Carl Troein

Summary, in English

Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.

Department/s

  • Computational Biology and Biological Physics - Undergoing reorganization

Publishing year

2016

Language

English

Publication/Series

PLoS ONE

Volume

11

Issue

2

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Bioinformatics and Systems Biology
  • Other Physics Topics
  • Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1932-6203