
Anders Irbäck
Professor

Binary assignments of amino acids from pattern conservation
Author
Summary, in English
We have developed a simple optimization procedure for assigning binary values to amino acids. The binary values are determined by a maximization of the degree of pattern conservation in groups of closely related protein sequences. The maximization is carried out at fixed composition. For compositions approximately corresponding to an equipartition of the residues, the optimal encoding is found to be strongly correlated with hydrophobicity. The stability of the procedure is demonstrated. Our calculations are based upon sequences in the SWISS-PROT database.
Department/s
- Computational Biology and Biological Physics - Undergoing reorganization
Publishing year
1997-09
Language
English
Pages
1013-1017
Publication/Series
Protein Engineering
Volume
10
Issue
9
Document type
Journal article
Publisher
Oxford University Press
Keywords
- Amino Acids
- Databases, Factual
- Fourier Analysis
- Models, Chemical
- Peptide Mapping
- Protein Folding
- Proteins
Status
Published
ISBN/ISSN/Other
- ISSN: 0269-2139