PROFASI: A Monte Carlo simulation package for protein folding and aggregation
Summary, in English
We present a flexible and efficient program package written in C++, PROFASI, for simulating protein folding and aggregation. The systems are modeled using an all-atom description of the protein chains with only torsional degrees of freedom, and implicit water. The program package has a modular structure that makes the interaction potential easy to modify. The currently implemented potential is able to fold several peptides with about 20 residues, and has also been used to study aggregation and force-induced unfolding. The simulation methods implemented in PROFASI are Monte Carlo-based and include a semilocal move and simulated tempering. Adding new updates is easy. The code runs fast in both single- and multi-chain applications, as is illustrated by several examples. (C) 2006 Wiley Periodicals, Inc.
- Computational Biology and Biological Physics - Undergoing reorganization
- Department of Astronomy and Theoretical Physics - Undergoing reorganization
Journal of Computational Chemistry
John Wiley & Sons Inc.
- protein folding
- Monte Carlo
- all-atom model
- protein aggregation
- ISSN: 1096-987X