Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.

Summary, in English

There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.

• Författare: Maria Björkqvist; Mattias Ohlsson; Lennart Minthon; Oskar Hansson
• Avdelning/ar: Biomarkörer vid hjärnsjukdomar; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Klinisk minnesforskning; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2012
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 7
• Issue: 1
• Fulltext: - 135 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/22279551?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0029868
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Neurology; Neurosciences
• Status: Published
• Forskningsgrupp: Biomarkers in Brain Disease; Clinical Memory Research
• ISBN/ISSN/Övrigt: ISSN: 1932-6203