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Maria Hansson. Foto.

Maria Hansson

Universitetslektor

Maria Hansson. Foto.

Estrogen receptor genes in gastropods : phylogenetic divergence and gene expression responses to a synthetic estrogen

Författare

  • Cecilia L. Hultin
  • Per Hallgren
  • Maria C. Hansson

Summary, in English

Endocrine disrupting chemicals (EDCs) have the potential to affect development and reproduction in gastropods. However, one is today lacking basic understanding of the Molluscan endocrine system and one can therefore not fully explain these EDC-induced affects. Furthermore, only a few genes that potentially may be connected to the endocrine system have been sequenced in gastropods. An example is the estrogen receptor gene (er) that have been identified in a restricted number of freshwater and marine gastropods. Here, we have identified a new partial coding sequence of an estrogen receptor gene (er) in the European common heterobranch Radix balthica. The following phylogenetic analysis divided the ers of heterobranchs and ceanogastropods in two branches. Furthermore, exposure to the synthetic estrogen 17α-ethinylestradiol (EE2) showed that exposure could significantly affect er expression level in the heterobranch R. balthica. This paper is the first that phylogenetically compares gastropods' er, basal er expression profiles, and transcriptional estrogenic responses in gastropods from two different evolutionary groups.

Avdelning/ar

  • Centrum för miljö- och klimatvetenskap (CEC)
  • Division aquatic ecology

Publiceringsår

2016-11-01

Språk

Engelska

Sidor

17-21

Publikation/Tidskrift/Serie

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

Volym

189

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Genetics
  • Environmental Sciences

Nyckelord

  • 17α-Ethinylestradiol
  • Estrogen receptor
  • Gastropods
  • Phylogenetic analysis

Aktiv

Published

Projekt

  • Estrogen receptor and multixenobiotic resistance genes in freshwater fish and snails: identification and expression analysis after pharmaceutical exposure

ISBN/ISSN/Övrigt

  • ISSN: 1532-0456