PROFASI: A Monte Carlo simulation package for protein folding and aggregation

Summary, in English

We present a flexible and efficient program package written in C++, PROFASI, for simulating protein folding and aggregation. The systems are modeled using an all-atom description of the protein chains with only torsional degrees of freedom, and implicit water. The program package has a modular structure that makes the interaction potential easy to modify. The currently implemented potential is able to fold several peptides with about 20 residues, and has also been used to study aggregation and force-induced unfolding. The simulation methods implemented in PROFASI are Monte Carlo-based and include a semilocal move and simulated tempering. Adding new updates is easy. The code runs fast in both single- and multi-chain applications, as is illustrated by several examples. (C) 2006 Wiley Periodicals, Inc.

• Författare: Anders Irbäck; Sandipan Mohanty
• Avdelning/ar: Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 1548-1555
• Publikation/Tidskrift/Serie: Journal of Computational Chemistry
• Volym: 27
• Issue: 13
• Länkar: http://dx.doi.org/10.1002/jcc.20452
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Biophysics
• Nyckelord: protein folding; Monte Carlo; all-atom model; plus; protein aggregation; C
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1096-987X