Anders Irbäck
Professor
Binary assignments of amino acids from pattern conservation
Författare
Summary, in English
We have developed a simple optimization procedure for assigning binary values to amino acids. The binary values are determined by a maximization of the degree of pattern conservation in groups of closely related protein sequences. The maximization is carried out at fixed composition. For compositions approximately corresponding to an equipartition of the residues, the optimal encoding is found to be strongly correlated with hydrophobicity. The stability of the procedure is demonstrated. Our calculations are based upon sequences in the SWISS-PROT database.
Avdelning/ar
- Beräkningsbiologi och biologisk fysik - Har omorganiserats
Publiceringsår
1997-09
Språk
Engelska
Sidor
1013-1017
Publikation/Tidskrift/Serie
Protein Engineering
Volym
10
Issue
9
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Nyckelord
- Amino Acids
- Databases, Factual
- Fourier Analysis
- Models, Chemical
- Peptide Mapping
- Protein Folding
- Proteins
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0269-2139