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Identification of kidney tumor tissue by infrared spectroscopy of extracellular matrix

  • Vidita Urboniene
  • Milda Pucetaite
  • Feliksas Jankevicius
  • Arunas Zelvys
  • Valdas Sablinskas
  • Gerald Steiner
Publishing year: 2014-08
Language: English
Publication/Series: Journal of Biomedical Optics
Volume: 19
Issue: 8
Document type: Journal article
Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society

Abstract english

Fourier transform infrared (FT-IR) spectroscopy was applied to characterize the extracellular matrix (ECM) of kidney tumor tissue and normal kidney tissue. Freshly resected tissue samples from 31 patients were pressed on a CaF2 substrate. FT-IR spectra obtained from ECM of tumor tissue exhibit stronger absorption bands in the spectral region from 1000 to 1200 cm−1 and around 1750 cm−1 than those obtained from normal tissue. It is likely that the spectra of ECM of kidney tumor tissue with large increases in the intensities of these
bands represent a higher concentration of fatty acids and glycerol. Amide I and amide II bands are stronger in the spectra of ECM from normal tissue, indicating a higher level of proteins. Our results suggest that FT-IR spectroscopy of the ECM is an innovative emerging technology for real-time intraoperative tumor diagnosis, which may improve margin clearance in renal cancer surgery.


  • ISSN: 1083-3668
Milda Pucetaite. Photo.
E-mail: milda [dot] pucetaite [at] cec [dot] lu [dot] se


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