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Photo of Mattias Ohlsson

Mattias Ohlsson

Professor

Photo of Mattias Ohlsson

The added value of ECG-gating for the diagnosis of myocardial infarction using myocardial perfusion scintigraphy and artificial neural networks

Author

  • Peter Gjertsson
  • Milan Lomsky
  • Jens Richter
  • Mattias Ohlsson
  • Deborah Tout
  • Andries van Aswegen
  • Richard Underwood
  • Lars Edenbrandt

Summary, in English

To assess the value of ECG-gating for the diagnosis of myocardial infarction using myocardial perfusion scintigraphy (MPS) and an artificial neural network. A total of 422 patients referred for MPS were studied using a one day Tc-99m-tetrofosmin protocol. Adenosine stress combined with submaximal dynamic exercise was used. The images were interpreted by one of three experienced clinicians and these interpretations regarding the presence or absence of myocardial infarction were used as the standard. A fully automated method using artificial neural networks was compared with the clinical interpretation. Either perfusion data alone or a combination of perfusion and function from ECG-gated images were used as input to different artificial neural networks. After a training session, the two types of neural networks were evaluated in separate test groups using an eightfold cross-validation procedure. The neural networks trained with both perfusion and ECG-gated images had a 4-7% higher specificity compared with the corresponding networks using perfusion data only, in four of five segments compared at the same level of sensitivity. The greatest improvement in specificity, from 70% to 77%, was seen in the inferior segment. In the septal and lateral segments the specificity rose from 73% to 77% and from 81% to 85%, respectively. In the anterior segment, the increase in specificity from 93% to 94% by adding functional data was not significant. The addition of functional information from ECG-gated MPS is of value for the diagnosis of myocardial infarction using an automated method of interpreting myocardial perfusion images.

Department/s

  • Computational Biology and Biological Physics - Has been reorganised

Publishing year

2006

Language

English

Pages

301-304

Publication/Series

Clinical Physiology and Functional Imaging

Volume

26

Issue

5

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Physiology and Anatomy

Keywords

  • radionuclide imaging
  • neural networks
  • myocardial infarction
  • image interpretation
  • computer assisted
  • heart function tests

Status

Published

ISBN/ISSN/Other

  • ISSN: 1475-0961