Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Summary, in English

B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

• Author: Frida Pauly; Karin E Smedby; Mats Jerkeman; Henrik Hjalgrim; Mattias Ohlsson; Richard Rosenquist; Carl A K Borrebaeck; Christer Wingren
• Department/s: Department of Immunotechnology; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Department of Astronomy and Theoretical Physics - Has been reorganised; Create Health
• Publishing year: 2014
• Language: English
• Pages: 682-690
• Publication/Series: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
• Volume: 38
• Issue: 6
• Full text: - 3 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24754901?dopt=Abstract; http://dx.doi.org/10.1016/j.leukres.2014.03.010
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1873-5835